![]() One of these studies used phage display technology to isolate a human monoclonal antibody (hmAb), designated m102.4 ( Zhu et al., 2008). These data have been corroborated in multiple studies by investigators using murine, rabbit, or human antibody discovery technologies to isolate potently neutralizing antibodies to HeV and/or NiV ( Aguilar et al., 2009 Mire et al., 2020 Zhu et al., 2006). Passive immune transfer studies in both hamsters and ferrets have provided evidence that neutralizing antibodies are a correlate of immunoprotection from henipaviruses ( Bossart et al., 2009 Guillaume et al., 2004, 2006). The risk of a global health crisis associated with henipaviruses is exacerbated by the lack of licensed antiviral drugs or vaccines for Henipavirus (HNV) and a dearth of knowledge of the human immune response to these viruses ( Escaffre et al., 2013 Gómez Román et al., 2020). Such consideration prompted the World Health Organization (WHO) to designate henipavirus infections as priority diseases requiring extensive and immediate research and development ( Sweileh, 2017). While HeV and NiV outbreaks historically have been confined geographically to Australia and Southeast Asia, respectively, the risk of pandemic spread of these highly pathogenic agents related to regional and global population densities and the difficulty of avoiding international transmission via infected travelers have been highlighted by recent experience with SARS-CoV-2 ( Morens and Fauci, 2020). These factors together with their resultant increase in intermediate host contact (humans and domestic animals) are associated with increasing geographic range and frequency of henipavirus disease spillover ( Martin et al., 2018 Walsh et al., 2017). Anthropogenic and climatic influences on flying foxes are affecting their roosting, feeding, and migration habits as well as their susceptibility to heat-stress, disease, and injury ( Kessler et al., 2018 Plowright et al., 2015). More direct routes of infection, including human-to-human transmission, and mortality rates approaching 100% have been observed during recent NiV outbreaks ( Chadha et al., 2006 Clayton et al., 2012 Gurley et al., 2007). NiV, which was discovered 4 years after HeV when hundreds of pig handlers fell ill with encephalitic disease ( Chua et al., 1999), has continued to cause sporadic outbreaks in Bangladesh and India ( Arunkumar et al., 2019 Soman Pillai et al., 2020). Spillover has occurred sporadically with some seasonal and climatic trends since then, causing disease in 105 horses and 7 humans, with high case fatality rates ( Queensland Government, 2020). HeV was identified in 1994, having caused the death of 14 of 21 infected horses and 1 of 2 infected humans in Queensland, Australia ( Murray et al., 1995b Selvey et al., 1995). HeV is transmitted from flying foxes to horses and from horses to in-contact humans, causing severe respiratory and/or encephalitic disease mediated by endothelial vasculitis in both ( Escaffre et al., 2013 Field, 2016 Murray et al., 1995a). Multiple species of pteropid bats (flying foxes) act as reservoir hosts for these negative-sense, single-stranded RNA viruses in the Paramyxoviridae family with which they are understood to have co-evolved ( Chua et al., 2002 Halpin et al., 2011 Halpin et al., 2000 Vidgen et al., 2015). We look forward to seeing you 136 Bonita Rd in Meridian soon.Hendra virus (HeV) ( Guirakhoo et al., 2002) and Nipah virus (NiV), the prototypic henipaviruses, are emerging zoonotic paramyxoviruses known to cause severe disease in humans and diverse other mammalian orders. Hearing protection, safety glasses, welding helmets, safety gloves, respirators, confined-space monitoring equipment, fall protection, and hardhatsĬheck with this Meridian branch for specific product availability as it varies throughout the year.Abrasive discs, cut-off and grinding wheels.Welding and cutting tips, welding wire and filler metal.Welding supplies and machines for MIG, TIG and stick welding applications, MIG guns and TIG torches.Gas regulators, plasma cutting equipment and consumables.Argon, oxygen, acetylene, nitrogen, carbon dioxide plus specialty and medical gases. ![]() And, you can take advantage of one-stop shopping for items such as: Our helpful branch associates at 136 Bonita Rd in Meridian can answer your questions and work with you to improve productivity and find solutions to help you succeed. You’ll find everything you need to get more done. What can I find at the Meridian, Mississippi Airgas branch? Come see us at the Airgas retail branch location at 136 Bonita Rd in Meridian to get the industrial and specialty gases, welding and safety products you need, along with the personal service you want.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |